In recent years, CTCs that escape from the primary tumor, intravasation into and survival in the blood circulation, extravasation the circulation and colonization growth in the metastatic site are considered to be a vital indicator for postoperative recurrence and metastasis of malignant tumors and show extremely significant clinical value in tumor diagnosis, dynamic detection of treatment response and prognosis evaluation ( Yu et al., 2013 ; Lin et al., 2021 ).
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Circulating tumor cells participate in the formation of microvascular invasion and impact on clinical outcomes in hepatocellular carcinoma.
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