Two of the three tumor types in which NKIRAS1 was not down-regulated in this analysis, KIRC and lung adenocarcinoma (LUAD), showed a nonsignificant trend toward downregulation ( Fig. 3 H ).
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A pan-cancer analysis implicates human <i>NKIRAS1</i> as a tumor-suppressor gene.
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We also noted a highly significant co-occurrence of deletion or mutation of TP53 , the gene encoding p53 in humans, and genomic loss of NKIRAS1 and NKIRAS2 , although with a moderately high odds ratio ( Fig. 3 C and D and SI Appendix , Fig.