Lysosomal alterations and decreased electrophysiological activity in CLN3 disease patient-derived cortical neurons.

Although CLN3 and CLN3-Cor neurons demonstrated an increasing trend in network burst duration during DIV 4-34 [peak; CLN3, 2.42 s (DIV 33); CLN3-Cor, 6.52 s (DIV 34)], network burst duration was longer in CLN3-Cor neurons than in CLN3 neurons from DIV 9 to DIV 42 (mean; CLN3, 1.04 s; CLN3-Cor, 3.48 s; Fig. 6 I).

also in 63,971 other papers

The ratio of LAMP1 120 kDa/90 kDa bands showed a decreasing trend from DIV 14 to DIV 42 ( Fig. 3 C).

also in 47,180 other papers