Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons.

For example, if a mediator’s mediation effect is completed mediated by other mediators, it may not be significant in the outcome model, but it is still “active” somewhere in the causal network among the mediators. 3.The simulation setting appears to resemble a setting with inconsistent mediation in which half of the mediators have positive mediation effects and the other half have negative mediation effects, and they partially cancel each other out.

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