marginally significantP = 0.052
Longitudinal Effects of Anticholinergic Burden GEE analysis revealed a significant main effect of group ( χ 2 = 51.26, df = 2, P < 0.001), a significant main effect of time ( χ 2 = 25.70, df = 1, P < 0.001) and a marginally significant interaction between group and time ( χ 2 = 5.92, df = 2, P = 0.052; Figure 1B ).