Obacunone targets macrophage migration inhibitory factor (MIF) to impede osteoclastogenesis and alleviate ovariectomy-induced bone loss.

Other highly significant pathways, including cytokine-cytokine receptor interaction, chemokine signaling, and TNF signaling pathways ( Fig. 3 C, Table S1 ), were also well-known to promote osteoclast differentiation.

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