However, it is noteworthy that this complication is rare and has shown a decreasing trend over time. 145–147 Moreover, the FDA has revised the metformin label to reflect its safety use in patients with an estimated glomerular filtration rate (eGFR) of 30 mL/min/1.73 m 2 . 143 Studies on metformin have also made considerable progress in understanding the genetic basis underlying its therapeutic response.
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