(It should be noted, however, that the process that drives this even spacing may not be significant enough to overcome the noise inherent to the system, and will be influenced by any inhomogeneities in the substrate.) Unfortunately, the spacing of multiple PLK4 peaks in cells overexpressing PLK4 has not been quantified, so one is left to interpret published images of multiple peaks, some of which might support equal spacing while others appear not to [ 40 , 41 ].
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A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly.
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