ASO-mediated knockdown or kinase inhibition of <i>G2019S</i>-Lrrk2 modulates lysosomal tubule-associated antigen presentation in macrophages.

Mol Ther Nucleic Acids · 2023 · PMC10661462 · PMID 38028198

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failed to reach significanceno p-value reported

Although Lrrk2 mRNA significantly decreased in vehicle-treated WTOE pMacs nucleofected with Lrrk2 -targeting ASO relative to control ASO, this failed to reach significance in IFNγ-treated WTOE pMacs.

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