Multifaceted immune dysregulation characterizes individuals at-risk for rheumatoid arthritis.

The DML overlap between the two cohorts was highly significant ( p = 1.71 × 10 −22 , 8.17 × 10 −33 and 3.13 × 10 −44 in B cell, memory T cell and Naïve T cells, respectively, by hypergeometric tests).

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