DNMT3B Alleviates Liver Steatosis Induced by Chronic Low-grade LPS via Inhibiting CIDEA Expression.

11 Clinical research also indicated that global DNA methylation yielded a decreasing trend in liver biopsy specimens of patients with NAFLD with increased fibrosis and inflammation progression. 12 The same analysis of genome-wide DNA methylation suggested HFD induced the hypomethylation of liver lipogenic genes, 13 which illustrates that the DNA methylation is critical for NAFLD progression.

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