Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces Pancreatitis-associated Acute Lung Injury.

To test this interpretation, we treated BMDNs with GSK-7975A (MCE, USA) to block SOCE through ORAI1 channels and observed that GSK-7975A significantly inhibited fMLP-induced intracellular Ca 2+ entry at both 1 and 10 μ m with a trend toward significance for an increased number of arrested and decreased number of shape-polarized neutrophils ( Figure 3E – G ).

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