Mechanism of Action of Natural Dipeptidyl Peptidase-IV Inhibitors (Berberine and Mangiferin) in Experimentally Induced Diabetes with Metabolic Syndrome.

Monotherapy groups MET (100 mg/kg), VIL (10 mg/kg), BER (100 mg/kg), and MNG (40 mg/kg) treatment significantly increased ( P < 0.05) the insulin levels as compared to HF-DC at the end of the 10 th week, However, increase in serum insulin was highly significant ( P < 0.001) in combination groups MET + VIL (100 + 10 mg/kg), MET + BER (100 + 100 mg/kg), and MET + MNG (100 + 40 mg/kg) insulin as compared with HF-DC group at the end of the 10 th week.

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