The Contribution of Hippocampal All-Trans Retinoic Acid (ATRA) Deficiency to Alzheimer's Disease: A Narrative Overview of ATRA-Dependent Gene Expression in Post-Mortem Hippocampal Tissue.

Antioxidants (Basel) · 2023 · PMC10669734 · PMID 38001775

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In this study, we showed that there is a highly significant downregulation of hippocampal RBP4 ( Table 1 ), which suggests impaired vascular transport of retinol from the liver to distant tissues, including the brain, assuming that hippocampal RBP4 downregulation is reflective of a similar downregulation in the liver.

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