a statistical trendp -value = 0.052
During the intervention period, there was also no significant change in the anthropometric measures after adjustment for age and gender in the three intervention groups (metformin, saffron and placebo) ( p -value > 0.05), except for a statistical trend to lower the mean BMI z-score in the saffron and metformin groups, compared to the placebo ( p -value = 0.052).