CDK4/6 inhibition enhances SHP2 inhibitor efficacy and is dependent upon RB function in malignant peripheral nerve sheath tumors.

To validate this finding, we carried out cell cycle distribution analysis in five NF1-MPNST cell lines (ST8814, NF10.1, JH-2-002, JH-2-079c, and JH-2-103) as an aggregate using flow cytometry, and we saw an increasing trend of percent cells in G 1 phase and a decreasing trend of percent cells in S phase when comparing cells treated with DMSO, TNO155, ribociclib, and the combination ( Fig. 6D ).

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