Endogenous FGF1 Deficiency Aggravates Doxorubicin-Induced Hepatotoxicity.

Consistent with this increasing trend, DOX treatment also significantly upregulated the mRNA expression of Nrf2 downstream genes including NQO1, HO-1 and SOD1 in WT mice; but these could only be seen for NQO1 expression in FGF1-KO mice, although an increasing trend could be observed for HO-1 and SOD1 expression ( Figure 2 D–G).

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