Investigating the Role of Anti-TPO Antibodies in HIV-Associated Thrombocytopenia before and after Initiation of HAART: A Case-Control Longitudinal Study.

In contrast, the anti-TPO (−) group displayed a highly significant difference in platelet counts across the time points ( p < 0.001), with a similar median increase in the platelet count (48,500 [IQR: (−2000) to 101,500]).

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Within the anti-TPO (+) group, a marginally significant alteration in median platelet counts was noted between the two time points—before and after HAART initiation ( p = 0.048)—with a median increase of 51,000 (IQR: (−5000) to 112,000).

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Moreover, antiretroviral therapy shows a marginal trend of decreasing anti-TPO (+) prevalence; however, seroconversion does not seem to be related to the severity of the initial thrombocytopenia.

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