A Study of Stromal Collagen in Oral Lichen Planus, Carcinoma In situ, Early Invasive Squamous Cell Carcinoma, and Normal Mucosa Using Picrosirius Red Stain

J Microsc Ultrastruct · 2022 · PMC10679824

Europe PMC

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highly significantno p-value reported

s as the tumor grade increased.[ 16 , 17 ] The poor packing of collagen fibers in these lesions could be attributed to collagenases secreted by altered epithelial cells or tumor cells and also the secretion of the abnormal matrix by the invasive tumor islands.[ 10 ] Intergroup comparison revealed a highly significant difference in collagen thickness in OLP compared to EISCC and the control group.

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