MMP-2 expression increased significantly after ureteral obstruction at d7 and d14 in WT and Tlr2 -/- mice ( Fig 7D ), with a slightly increasing trend for Tlr2 -/- kidneys, but without significant differences between the two lines.
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TLR2 mediates renal apoptosis in neonatal mice subjected experimentally to obstructive nephropathy.
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