Dendrobium mixture ameliorates hepatic injury induced by insulin resistance <i>in vitro</i> and <i>in vivo</i> through the downregulation of AGE/RAGE/Akt signaling pathway.

Heliyon · 2023 · PMC10685200 · PMID 38034607

Europe PMC DOI

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an increasing trendp < 0.05actually significant

In contrast, the DM treatment group exhibited an increasing trend in the ratio of LC3II/LC3I, significantly higher levels of p -AMPK/AMPK ( p < 0.05), and reduced levels of p -mTOR/TOR ( p < 0.01).

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a decreasing trendno p-value reported

5 d and e, the PA group showed a decreasing trend in the LC3II/LC3I ratio, suggesting that PA induced insulin resistance and glucose metabolism disorder in HepG2 cells were associated with an inhibited autophagy activity.

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