SPINK1-induced tumor plasticity provides a therapeutic window for chemotherapy in hepatocellular carcinoma.

Nat Commun · 2023 · PMC10687140 · PMID 38030644

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highly significantno p-value reported

Despite having the proliferation markers omitted, HCC tumors with high SPINK1 still show highly significant enrichments of stem cell signatures, suggesting that the stemness signature is independent of the proliferation status.

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