Optimization of nutritional strategies using a mechanistic computational model in prediabetes: Application to the J-DOIT1 study data.

If, for instance, both weight and HbA1c showed a decreasing trend over multiple observations, it was assumed that a single diet change at the beginning of the observation period should be able to explain all the observations.

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Whenever a previously decreasing trend in either body weight or HbA1c was followed by an increasing trend or vice-versa, a lifestyle change was introduced, assuming that such changes in body weight or HbA1c could only be driven by lifestyle factors.

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