BMP-4 A highly significant and narrow spatiotemporal peak at around 15Y post-surgery suggests that BMP-4 is primarily involved in the late phase of coupled bone remodeling characterized by extensive regulatory interaction between osteoblasts, osteocytes and osteoclasts with the aim of fine-tuning bone repair activity and maintaining bone homeostasis ( Gerstenfeld et al., 2003 ).
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The importance of BMPs and TGF-βs for endochondral bone repair - A longitudinal study in hip arthroplasty patients.
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