Atypical genotoxicity of carcinogenic nickel(II): Linkage to dNTP biosynthesis, DNA-incorporated rNMPs, and impaired repair of TOP1-DNA crosslinks.

J Biol Chem · 2023 · PMC10692736 · PMID 37890780

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highly significantno p-value reported

Quantitation of data from three biological replicates confirmed a highly significant, several-fold decrease in TOP1-DPC ubiquitination by Ni(II) in both control and siRNaseH2B-depleted cells ( Fig. 8 I ).

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