Quantifying spatial dynamics of Mycobacterium tuberculosis infection of human macrophages using microfabricated patterns.

Surprisingly, in M1 there was a 35% increase in the number of cells with the MTOC in the polarized quadrant when infected with H37Rv, relative to uninfected, while for M2 a 48% decrease in cells with the MTOC in the polarized quadrant was observed when H37Rv-infected M2 were compared with uninfected M2 ( Figure 4 D), with a trend toward significance compared with uninfected cells for M1 but not M2 (M1 p = 0.079, M2 p = 0.494).

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