RAGE engagement by SARS-CoV-2 enables monocyte infection and underlies COVID-19 severity.

Looking more in depth at the specific differences in the immune response pathway of each cell family in severe/critical versus mild patients ( Figure 2 C), in line with previous reports, 32 we observed a strong enrichment in family pathways associated with the IFN signaling and antiviral response, mainly in B, myeloid, and NK cells, with a decreasing trend of expression over time, independent from patients’ severity.

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