On day 27, the patient developed acute GVHD and received therapeutic IV-MTX administration (5 mg/m 2 ) after which, C ss started to increase, and the ratio of C ss to the daily TCR dose (C/D), a surrogate marker of TCR clearance, showed an increasing trend until day 30 (Fig. 1 ).
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Elevation of tacrolimus concentration after administration of methotrexate for treatment of graft-versus-host disease in pediatric patients received allogeneic hematopoietic stem cell transplantation.
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