RNA binding protein IGF2BP2 expression is induced by stress in the heart and mediates dilated cardiomyopathy.

Commun Biol · 2023 · PMC10698010 · PMID 38052926

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highly significantno p-value reported

This highly significant correlation ( χ 2 < 0.0001) indicates that IGF2BP2 expression in the heart causes mitochondrial proteins, and, as a result, mitochondrial metabolism, to be greatly diminished; non-mitochondrial metabolic pathways, in contrast, are upregulated, apparently in an attempt to compensate for the heart’s metabolic requirements.

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