Candidate open reading frames D10L (host range), B10R (virulence factor for myxoma virus), B14R (interleukin (IL)-1 binding protein), and B19R (serine protease inhibitor-1) are further candidates that may be significant for the virulence and transmissibility of Congo Basin MPXV isolates [16 , 26 , 27] . 3.5 Immune evasion Numerous mechanisms have been developed by orthopoxviruses in general and monkeypox in specific to evade the host's immune response [32] .
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