Quercetin improves and protects Calu-3 airway epithelial barrier function.

Specifically, we observed a statistically significant 25% decrease in claudin-2, a 20% decrease in claudin-3, and a borderline significant ( p < 0.05, one-tailed Student’s t-test) 35% decrease in claudin-5 because of quercetin treatment.

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By 24 h, this situation reversed completely, with a 30% highly significant decrease in TER and an over 150% increase in 14 C-D-mannitol leak compared to time-matched controls.

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