Treatment with the PPARα agonist fenofibrate improves the efficacy of CD8⁺ T cell therapy for melanoma.

Although some CD8 + T cells could be recovered from group B, this failed to reach significance compared to the low numbers of cells that exhibited non-specific staining in groups C and D.

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Group A T cells compared to group B T cells showed highly significant increases in transcripts for enzymes of fatty acid metabolism and decreases in those of glycolysis and histone methyltransferase (HMT), an enzyme of one-carbon metabolism ( Figure 3 G), as would be expected upon PPARα activation.

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