The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes.

EMBO Rep · 2023 · PMC10702814 · PMID 37846480

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highly significantno p-value reported

A highly significant correlation was observed between strong mTOR and low HACE1 expression in these tumors (Fig 6E and F ), highlighting the inverse relationship between HACE1 and mTOR levels in SCLC tumors in vivo .

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