Integrated Genomic Analysis of Primary Prostate Tumor Foci and Corresponding Lymph Node Metastases Identifies Mutations and Pathways Associated with Metastasis.

In addition, we performed GSEA on all primary tumor foci from African-American and White patients controlling for Gleason score ( Supplementary Table S10 ) and found that oxidative phosphorylation was highly significant (FDR < 2.2 × 10 −16 ) along with the interferon alpha response, UV response, adipogenesis, mitotic spindle, and estrogen response.

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