on the threshold of significancep = 0.051
Despite ICOSLG, only being higher expressed in patients with an above-median PFS at T 0 , there was a trend towards patients with above-median PFS rates having higher levels of ICOSLG at T 2 , which was on the threshold of significance ( p = 0.051), while no trend was observed at T 1 ( p = 0.29). 3.3.