The MYC-Regulated RNA-Binding Proteins hnRNPC and LARP1 Are Drivers of Multiple Myeloma Cell Growth and Disease Progression and Negatively Predict Patient Survival.

First, we found a highly significant correlation between MYC expression and expression of 4EBP1, LARP1, and hnRNPC in primary material from 762 newly diagnosed MM patients in the MMRF CoMMpass study ( NCT01454297 ) [ 24 ] ( Figure 7 A).

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