Life-Cycle-Dependent Toxicities of Mono- and Bifunctional Alkylating Agents in the 3R-Compliant Model Organism <i>C. elegans</i>.

Cells · 2023 · PMC10705807 · PMID 38067156

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a nonsignificant trendno p-value reported

In this experiment, once again, the effect was compound-specific, with significantly higher susceptibility to CEES for pme-2 , parg-2 , and sirt-2.1 mutants ( Figure 7 a), whereas upon HN2 treatment, only parg-2 survival was significantly reduced, while pme-2 and sirt-2.1 showed a nonsignificant trend ( Figure 7 b).

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