Pyruvate Kinase Differentially Alters Metabolic Signatures during Head and Neck Carcinogenesis.

In the aspect of cell biomass, the mRNA expression of key enzymes Transketolase (TK) and Transaldolase (TA) of the P entose P hosphate P athway (PPP, a metabolic pathway parallel to glycolysis that generates the nucleotide precursor ribose-5-phosphate) showed a decreasing trend in PKM2-silencing HNSC cells compared to control cells ( Figure S8 ).

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