Asperulosidic Acid Ameliorates Renal Interstitial Fibrosis via Removing Indoxyl Sulfate by Up-Regulating Organic Anion Transporters in a Unilateral Ureteral Obstruction Mice Model.

Molecules · 2023 · PMC10707915 · PMID 38067420

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a decreasing trendno p-value reported

In this paper, we found that, with the increase in the plasma concentration of IS, there was a decreasing trend of OAT1/3 expression during the renal fibrosis process, while the expressions of MRP4 and ABCG2 increased, indicating that the accumulation of IS is directly related to the decrease in OAT expression.

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