Metformin alleviates hepatic iron overload and ferroptosis through AMPK-ferroportin pathway in HFD-induced NAFLD.

iScience · 2023 · PMC10711470 · PMID 38089577

Europe PMC DOI

hedged sentence

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

marginally significantp = 0.07so close (0.05 < p ≤ 0.1)

found a marginally significant differences in cellular iron between AMPK double knockout cells and the wild type cells (p = 0.07–0.09). 43 More studies are needed to dissect the role of AMPK or metformin on ferroptosis or cellular iron metabolism.

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