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SIMPD: an algorithm for generating simulated time splits for validating machine learning approaches.

J Cheminform · 2023 · PMC10712068 · PMID 38082357

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an overall trendno p-value reported
Typically, this leads to an overall trend of increasing potency from the earliest to the most recent compounds.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.