highly significantP = 2.14 × 10 −8
The effect of INH + STR resistance on THD in L2.2.1 isolates was also highly significant when incorporating multidimensional scaling (MDS) components as covariates in linear regression ( P = 2.14 × 10 −8 ), suggesting that substructure within the L2.2.1 sublineage was not driving the association.