highly significantP < 0.001
* P < 0.05 statistically significant; ** P < 0.01 highly significant; and *** P < 0.001 and **** P < 0.0001 extremely significant.
* P < 0.05 statistically significant; ** P < 0.01 highly significant; and *** P < 0.001 and **** P < 0.0001 extremely significant.