Changing prevalence of chronic hepatitis B virus infection in China between 1973 and 2021: a systematic literature review and meta-analysis of 3740 studies and 231 million people.

Analyses by finer time periods suggested a constant decline in HBsAg seroprevalence nationwide between 1973–1984 and 2019–2021 ( figure 2A ), which was highly significant in a linear regression model (−0.20% per year, p<0.0001; APC=−3.77, 95% CI −4.15 to –3.38) ( figure 2B ).

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9 Of note, we detected a significant increase in HBV prevalence among persons ≥60 years, although the period estimates of HBsAg seroprevalence from meta-analysis showed a decreasing trend.

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