Neuropilin-1 identifies a subset of highly activated CD8+ T cells during parasitic and viral infections.

PLoS Pathog · 2023 · PMC10718454 · PMID 38019895

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While unstimulated splenic CD8 + T cells from naïve C57BL/6 mice generally lacked Nrp-1 expression (mean 0.1%), in vitro stimulation with 1 μg αCD3/αCD28 resulted in a highly significant increase in Nrp-1-expressing CD8 + T cells with a maximum of 36% Nrp-1 + CD8 + T cells after 48 hours of stimulation ( Fig 4A ).

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