Metformin effects on cardiac parameters in non-diabetic Iraqi patients with heart failure and mid-range ejection fraction - a comparative two-arm parallel clinical study.

J Med Life · 2023 · PMC10719796 · PMID 38107711

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borderline significantno p-value reported

Evidence that initial therapies used in combination (beta-blocker and angiotensin system blocker (ARNI or ACEI)) prolong survival [ 7 , 8 ] and reduce mortality compared to placebo was borderline significant for ARB therapy (used as an alternative to ARNI or ACEI) and for isosorbide dinitrate-hydralazine therapy (used as an alternative to an angiotensin system blocker) [ 9 ].

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