Psilocybin-induced default mode network hypoconnectivity is blunted in alcohol-dependent rats.

Transl Psychiatry · 2023 · PMC10721862 · PMID 38097569

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GBC analysis revealed a highly significant wide-spread cluster of psilocybin-induced decreased average connectivity strength 18 min after drug administration in comparison to placebo (Fig. 2A , p FWE cluster-corrected < 0.05; cluster-defining threshold of t > 2.53 (corresponding to p CDT < 0.01, dark blue) and t > 3.55 (corresponding to p CDT < 0.001, light blue), respectively).

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