Notably, we observed robust and highly significant correlations between potencies in the HTR assay and in vitro 5-HT 2A R potency measures, including binding affinities ( K i ) measured using [ 3 H]-ketanserin, and functional potencies (EC 50 ) for activating Gq and β-arrestin2 via 5-HT 2A R (Supplementary Fig. 10B-F ).
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Identification of 5-HT<sub>2A</sub> receptor signaling pathways associated with psychedelic potential.
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