What Is the Current Best Drug Treatment for Hypertensive Heart Failure With Preserved Ejection Fraction? Review of the Totality of Evidence.

Am J Hypertens · 2024 · PMC10724525 · PMID 37551929

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0510

boldest claim

The sentences

borderline significanceP = 0.051so close (0.05 < p ≤ 0.1)

Nevertheless, borderline significance ( P = 0.051) was achieved in favor of candesartan in the CHARM study after prespecified adjustments for covariates.

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borderline significantno p-value reported

Although PEP-CHF did not enroll the planned number of participants, the 1-year interim analysis showed a borderline significant effect on the primary endpoint, a composite of mortality and hospitalization for HF worsening.

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