After each treatment with nusinersen, platelets showed a decreasing trend ( P 1 = 0.008, P 2 < 0.001, P 3 < 0.001, P 4 = 0.021; Figure 4 ), and platelets rebounded again before the next treatment with nusinersen. 3.6.
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Study on the efficacy, safety, and biomarkers of nusinersen in type II and III spinal muscular atrophy in children.
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